Dr Maxwell Damian
Maxwell S. Damian, MD, PhD (Habil), FNCS, FEAN Cambridge University Hospitals.
Max is an Australian neurologist and works in Germany and Cambridge, UK. His clinical and academic work has centred on neurointensive care and on the acute and emergency management of neuromuscular disease. He has been a member of the WMS since 2004 and is a Fellow of the Neurocritical Care Society and the European Academy of Neurology, where he chaired the Neurocritical Care Scientific Panel 2015-2020. He was the principal author of the WMS advice and practice parameter papers.
Jiri Vajsar MD, MSc, FRCPS.The Hospital for Sick Children (SickKids) and The University of Toronto, Canada
Jiri has a long-standing interest and expertise in paediatric neuromuscular diseases and he has been a member of the WMS for 25 years. His research and publications deal with SMA, muscular dystrophies, GBS and MG and his research has been funded by MDAC, NIH, SMA Foundation and Industry.
It is a unique time for neuromuscular disorders, as an unprecedented number of therapeutic candidates are entering clinical trial for a range of diseases. With this surge of potential treatments, the importance of pre-clinical models and rigor in pre-clinical drug development has never been more important. It is critical to evaluate study designs, predictive power, reliability and relevance of current animal models in assessing the efficacy and safety of emerging therapies. In this panel, we have assembled four world leading experts on the application of pre-clinical models to therapy development. We will present key ideas related to best practice and discuss important pitfalls that have plagued pre-clinical drug programs. We will also identify current gaps in the field and offer ideas for future improvements.
Dr James Dowling, Clinician-Scientist, The Hospital for Sick Children (SickKids); University of Toronto, Canada.
Dr Dowling received his BSc from Yale, his MD/PhD from University of Chicago, and completed residency at Children’s Hospital of Philadelphia. Dr. Dowling’s clinical expertise is in neuromuscular disorders, and his research examines disease pathogenesis and therapy development for congenital myopathies.
Grace Yoon, Staff physician in the Division of Clinical and Metabolic Genetics, The Hospital for Sick Children (SickKids); University of Toronto, Canada
She and Dr. Jim Dowling co-direct a multidisciplinary clinic which is dedicated to the care of children with genetic neuromuscular disorders.